gene

CLCN7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLCN7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

15Outgoing

8Incoming

0Experiments

0Debates

Summary

Chloride Voltage-Gated Channel 7 - lysosomal chloride channel critical for bone resorption and neuronal function

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🧬 Gene Info

Gene Symbol	CLCN7
Full Name	Chloride Voltage-Gated Channel 7
Chromosome	16p13.3
Protein Type	Channel
Function	is a member of the CLC chloride channel family, which comprises both plasma membrane channels and intracellular voltage-gated chloride channels.
Amino Acids	805 aa
UniProt ID	P51797
NCBI Gene ID	1191
Ensembl ID	ENSG00000132449
OMIM	602727
GeneCards	CLCN7
Human Protein Atlas	CLCN7
Bone	Osteoclasts — highly expressed, critical for bone resorption
Brain	Neurons, particularly in hippocampus, cortex, and substantia nigra
Kidney	Tubular cells
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AMPD2, GNAI3, GNPTG, WDR81
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLCN7 — AlphaFold P51797 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CLCN7 Gene

gene · 994 words

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Pathway Diagram

graph TD
    CLCN7["CLCN7"]
    Cardiovascular{"Cardiovascular"}
    CLCN7 -->|"expressed in"| Cardiovascular
    RIPK2["RIPK2"]
    CLCN7 -->|"expressed in"| RIPK2
    IFIH1["IFIH1"]
    CLCN7 -->|"expressed in"| IFIH1
    GNAI1["GNAI1"]
    CLCN7 -->|"expressed in"| GNAI1
    ATG16L1["ATG16L1"]
    CLCN7 -->|"expressed in"| ATG16L1
    GNG2["GNG2"]
    CLCN7 -->|"expressed in"| GNG2
    WDR81["WDR81"]
    CLCN7 -->|"activates"| WDR81
    GNPTG["GNPTG"]
    CLCN7 -->|"activates"| GNPTG
    GNAI2["GNAI2"]
    CLCN7 -->|"expressed in"| GNAI2
    NOD2["NOD2"]
    CLCN7 -->|"expressed in"| NOD2
    GNAS["GNAS"]
    CLCN7 -->|"expressed in"| GNAS
    GNAI3["GNAI3"]
    CLCN7 -->|"activates"| GNAI3
    AKT1["AKT1"]
    AKT1 -->|"expressed in"| CLCN7
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| CLCN7
    AKT["AKT"]
    AKT -->|"expressed in"| CLCN7
    GNB1["GNB1"]
    GNB1 -->|"expressed in"| CLCN7
    AMPD2["AMPD2"]
    AMPD2 -->|"activates"| CLCN7
    ATG5["ATG5"]
    ATG5 -->|"expressed in"| CLCN7
    MAVS["MAVS"]
    MAVS -->|"expressed in"| CLCN7
    TBK1["TBK1"]
    TBK1 -->|"expressed in"| CLCN7
    style CLCN7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Cardiovascular	expressed_in	disease	0.65
Autophagy	expressed_in	pathway	0.60
Wnt	expressed_in	pathway	0.60
Akt	expressed_in	pathway	0.60
RIPK2	expressed_in	gene	0.60
IFIH1	expressed_in	gene	0.60
GNAI1	expressed_in	gene	0.60
ATG16L1	expressed_in	gene	0.60
GNG2	expressed_in	gene	0.60
WDR81	activates	gene	0.60
GNPTG	activates	gene	0.60
GNAI2	expressed_in	gene	0.60
NOD2	expressed_in	gene	0.60
GNAS	expressed_in	gene	0.60
GNAI3	activates	gene	0.60

Incoming (8)

Source	Relation	Type	Str
AUTOPHAGY	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
GNB1	expressed_in	gene	0.60
AMPD2	activates	gene	0.60
ATG5	expressed_in	gene	0.60
MAVS	expressed_in	gene	0.60
TBK1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLCN7 in their description or question text

No additional research found