gene

GNG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

10Outgoing

13Incoming

0Experiments

0Debates

Summary

GNG2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with Cardiovascular. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GNG2
Full Name	G protein subunit gamma 2
Chromosome	14q21.3
Protein Family	G protein gamma subunit family
Function	encodes a critical component of heterotrimeric G proteins that mediate cellular signaling throughout the nervous system.
Molecular Weight	7.6 kDa
Amino Acids	71 aa
Exons	4
Pathways	PI3K
UniProt ID	[P59768](https://www.uniprot.org/uniprot/P59768)
Ensembl ID	ENSG00000186472
OMIM	606314
GeneCards	GNG2
Human Protein Atlas	GNG2
C-terminal CAAX motif	Cys-aliphatic-aliphatic-X sequence (Cys-Val-Ile-Ile in Gγ2)
Associated Diseases	neurodegeneration
Interactions	AKT, AKT1, ATG16L1, ATG5, AUTOPHAGY, GNAI1
KG Connections	23 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GNG2 Gene

gene · 2140 words

→

GNG2 Protein

protein · 589 words

→

Pathway Diagram

graph TD
    GNG2["GNG2"]
    Cardiovascular{"Cardiovascular"}
    GNG2 -->|"expressed in"| Cardiovascular
    WDR81["WDR81"]
    GNG2 -->|"expressed in"| WDR81
    GNPTG["GNPTG"]
    GNG2 -->|"expressed in"| GNPTG
    GNAI2["GNAI2"]
    GNG2 -->|"interacts with"| GNAI2
    NOD2["NOD2"]
    GNG2 -->|"interacts with"| NOD2
    GNAS["GNAS"]
    GNG2 -->|"interacts with"| GNAS
    GNAI3["GNAI3"]
    GNG2 -->|"interacts with"| GNAI3
    Autophagy(["Autophagy"])
    GNG2 -->|"interacts with"| Autophagy
    Wnt(["Wnt"])
    GNG2 -->|"expressed in"| Wnt
    Akt(["Akt"])
    GNG2 -->|"interacts with"| Akt
    neurodegeneration["neurodegeneration"]
    GNG2 -->|"implicated in"| neurodegeneration
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| GNG2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| GNG2
    AKT["AKT"]
    AKT -->|"interacts with"| GNG2
    GNB1["GNB1"]
    GNB1 -->|"interacts with"| GNG2
    AMPD2["AMPD2"]
    AMPD2 -->|"expressed in"| GNG2
    ATG5["ATG5"]
    ATG5 -->|"interacts with"| GNG2
    MAVS["MAVS"]
    MAVS -->|"interacts with"| GNG2
    TBK1["TBK1"]
    TBK1 -->|"interacts with"| GNG2
    CLCN7["CLCN7"]
    CLCN7 -->|"expressed in"| GNG2
    RIPK2["RIPK2"]
    RIPK2 -->|"interacts with"| GNG2
    IFIH1["IFIH1"]
    IFIH1 -->|"interacts with"| GNG2
    GNAI1["GNAI1"]
    GNAI1 -->|"interacts with"| GNG2
    style GNG2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Cardiovascular	expressed_in	disease	0.65
Autophagy	interacts_with	pathway	0.60
Wnt	expressed_in	pathway	0.60
Akt	interacts_with	pathway	0.60
WDR81	expressed_in	gene	0.60
GNPTG	expressed_in	gene	0.60
GNAI2	interacts_with	gene	0.60
NOD2	interacts_with	gene	0.60
GNAS	interacts_with	gene	0.60
GNAI3	interacts_with	gene	0.60

Incoming (13)

Source	Relation	Type	Str
AUTOPHAGY	interacts_with	gene	0.60
GNAI1	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
GNB1	interacts_with	gene	0.60
AMPD2	expressed_in	gene	0.60
ATG5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
CLCN7	expressed_in	gene	0.60
RIPK2	interacts_with	gene	0.60
IFIH1	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GNG2 in their description or question text

No additional research found