concept

EGFR MUTATIONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGFR MUTATIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

Summary

EGFR MUTATIONS is a concept in neurodegeneration research. Key relationships include: expressed in, associated with, inhibits. Associated with ALS, Als, Cancer. Connected to 87 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	EGFR MUTATIONS
Key Genes/Proteins	AKT, AND, APOPTOSIS, ATP, BCL2L1, CANCER
Related Diseases	Als, ALS, Cancer, Carcinoma, Colorectal Cancer
Related Pathways	Akt, Apoptosis, Cell Cycle

Pathway Diagram

graph TD
    EGFR_MUTATIONS["EGFR MUTATIONS"]
    EGFR_MUTATIONS -->|"causes"| cancer_progression["cancer progression"]
    EGFR_MUTATIONS -->|"causes"| lung_adenocarcinoma["lung adenocarcinoma"]
    EGFR_MUTATIONS -->|"contributes to"| Carcinoma["Carcinoma"]
    EGFR_MUTATIONS -->|"interacts"| Tumor["Tumor"]
    EGFR_MUTATIONS -->|"target for"| Als["Als"]
    EGFR_MUTATIONS -->|"regulates"| Ms["Ms"]
    EGFR_MUTATIONS -->|"regulates"| Cancer["Cancer"]
    EGFR["EGFR"] -->|"interacts"| EGFR_MUTATIONS
    CANCER["CANCER"] -->|"regulates"| EGFR_MUTATIONS
    AND["AND"] -->|"interacts"| EGFR_MUTATIONS
    IL1B["IL1B"] -->|"expressed in"| EGFR_MUTATIONS
    GENES["GENES"] -->|"expressed in"| EGFR_MUTATIONS
    BCL2L1["BCL2L1"] -->|"expressed in"| EGFR_MUTATIONS
    AKT["AKT"] -->|"expressed in"| EGFR_MUTATIONS
    CYTOKINES["CYTOKINES"] -->|"expressed in"| EGFR_MUTATIONS

Outgoing (80)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:EGFR MUTATIONS	data_in	dataset_row	0.00
EGFR	inhibits	gene	1.00
Carcinoma	inhibits	disease	0.95
Als	associated_with	disease	0.95
Lung Adenocarcinoma	associated_with	disease	0.95
Lung Adenocarcinoma	biomarker_for	disease	0.90
cancer progression	causes	phenotype	0.90
Lung Cancer	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
Lymphoma	inhibits	disease	0.85
Tumor	therapeutic_target	disease	0.85
Early-Stage Lung Adenocarcinoma	biomarker_for	disease	0.85
Asian Population Prevalence	associated_with	phenotype	0.85
lung adenocarcinoma	causes	disease	0.80
tumor heterogeneity	contributes_to	phenotype	0.80
CANCER	associated_with	gene	0.80
Lung Cancer	inhibits	disease	0.75
Cancer	inhibits	disease	0.75
Lung Cancer	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
CANCER	therapeutic_target	gene	0.70
EGFR	therapeutic_target	gene	0.70
Gastric Cancer	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Glioblastoma	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	treats	disease	0.65
Ms	therapeutic_target	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Carcinoma	contributes_to	disease	0.65
Tumor	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Glycolysis	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
PI3K	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
EGFR	interacts_with	gene	0.60
GENES	expressed_in	gene	0.60
ELF3	associated_with	gene	0.60
CYTOKINES	expressed_in	gene	0.60
ELF3	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60

Incoming (33)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:EGFR MUTATIONS	data_in	dataset_row	0.00
AKT	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
EGFR	interacts_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
EGFR	inhibits	gene	0.60
CCND1	expressed_in	gene	0.60
AND	inhibits	gene	0.60
AND	activates	gene	0.60
CANCER	regulates	gene	0.60
CANCER	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
EGFR	activates	gene	0.60
CANCER	activates	gene	0.60
AKT	activates	gene	0.60
EGFR	treats	gene	0.60
OVERVIEW	treats	gene	0.60
GLIOBLASTOMA	inhibits	gene	0.60
MET	therapeutic_target	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
EGF	inhibits	gene	0.60
IL1B	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
BCL2L1	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ELF3	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
EGFR	associated_with	gene	0.50
TUMOR	associated_with	disease	0.50
TUMOR	interacts_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EGFR MUTATIONS in their description or question text

No additional research found