| Gene Symbol | ERCC3 |
| Chromosome | 19q13.32. |
| Protein Type | Gene |
| Function | is a DNA repair gene located on chromosome 19q13. |
| Primary Expression | all human tissues, including: - Brain: neurons, astrocytes, microglia, oligodendroc |
| Molecular Weight | 89 kDa |
| Amino Acids | 782 aa |
| Exons | 17 |
| Pathways | Akt, Mtor, PI3K-AKT-mTOR signaling, Pi3K |
| GeneCards | ERCC3 |
| Human Protein Atlas | ERCC3 |
| Transcription initiation | ERCC3's helicase activity unwinds DNA at the promoter region, allowing RNA polymerase II to initiate transcription of neuronal genes |
| DNA repair | TC-NER removes bulky DNA lesions (UV-induced pyrimidine dimers, chemical adducts) that would otherwise block transcription |
| Neuronal survival | Proper DNA repair maintains genomic integrity in post-mitotic neurons, which cannot undergo replication-based repair |
| Associated Diseases | Als, Carcinoma, Cirrhosis |
| Interactions | AKT, AND, CCL2, CEBPB, CHKA, CYP1A2 |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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