gene 1,850 words KG: DGUOK
Contents

DGUOK — Deoxyguanosine Kinase

🧬 Gene Info
Gene SymbolDGUOK
Full NameDeoxyguanosine Kinase
Chromosome2p13.1
Protein FamilyDeoxyguanosine kinase family
Protein TypeEnzyme
Functionis a nuclear-encoded gene that encodes a crucial mitochondrial enzyme involved in the nucleotide salvage pathway.
Primary Expressionall human tissues with particularly high expression in liver, kidney, and brain
Subcellular Localizationthe mitochondrial matrix. Each subunit contains an N-terminal mitochondrial targeting peptide (approximately 30 amino ac
Molecular Weight34 kDa
Amino Acids278 aa
Exons7
UniProt ID[Q01459](https://www.uniprot.org/uniprot/Q01459)
Ensembl IDENSG00000198246
OMIM601465
GeneCardsDGUOK
Human Protein AtlasDGUOK
Associated Diseasesneurodegeneration
KG Connections32 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
PARP1 Inhibition Therapy
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Mitochondria
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Genes
index · KG edge: associated_with
mfn2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

POLG2 associated_with DGUOK
SLC25A4 associated_with DGUOK
MFN2 associated_with DGUOK
TYMP associated_with DGUOK
RRM2B associated_with DGUOK
TK2 associated_with DGUOK
SUCLA2 associated_with DGUOK
SUCLG1 associated_with DGUOK
TFAM associated_with DGUOK
POLG associated_with DGUOK

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