Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about snx2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SNX2 |
| Function | SNX2 (Sorting Nexin 2) is a key component of the membrane trafficking machinery with multiple essential cellular functions: |
| Molecular Weight | 47 kDa |
| Ensembl ID | ENSG00000136053 |
| GeneCards | SNX2 |
| Human Protein Atlas | SNX2 |
| VPS26/VPS29/VPS35 | The core cargo-selective complex |
| SNX2/SNX1 | The membrane-deforming BAR domain-containing components |
| Cargo Recognition | SNX2 can bind to ubiquitinated cargo destined for autophagic degradation |
| Membrane Bending | The BAR domain of SNX2 induces membrane curvature, facilitating the formation of transport carriers |
| Sorting Decisions | SNX2 helps distinguish between proteins destined for degradation in lysosomes and those destined for recycling to the TGN or plasma membrane |
| Autophagosome Formation | SNX2 contributes to the recruitment of autophagy machinery to nascent autophagosomes |
| Maturation | SNX2 plays a role in autophagosome-endosome/lysosome fusion |
| Amyloidogenesis | Reduced SNX2 expression or function leads to increased APP processing in endosomes, increasing Aβ production. Studies show that SNX2 knockdown increases Aβ secretion in cellular models. |
| Endosomal Dysfunction | AD is characterized by early endosomal vacuolization, and SNX2 dysfunction contributes to this phenotype. This endosomal dysfunction is one of the earliest pathological changes in AD. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["SNX2"]
N1["Als"]
N0 -->|"expressed in"| N1
N2["Cancer"]
N0 -->|"expressed in"| N2
N3["Tumor"]
N0 -->|"expressed in"| N3
N4["ATG10"]
N0 -->|"expressed in"| N4
N5["CANCER"]
N0 -->|"expressed in"| N5
N6["WIPI2"]
N0 -->|"expressed in"| N6
N7["CLN3"]
N7 -->|"expressed in"| N0
N8["GABARAPL2"]
N8 -->|"expressed in"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:SNX2 | data_in | dataset_row | 0.00 |
| CLN3 | expressed_in | gene | 0.60 |
| GABARAPL2 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning snx2 in their description or question text
No additional research found