gene 1,858 words KG: CLN3
Contents

CLN3 Gene - Ceroid Lipofuscinosis, Neuronal 3

🧬 Gene Info
Gene SymbolCLN3
AliasesBatten disease, Battenin
Functionencodes a lysosomal/endosomal transmembrane protein that is critical for neuronal function and survival.
Molecular Weight48 kDa
Amino Acids438 aa
Ensembl IDENSG00000158966
GeneCardsCLN3
Human Protein AtlasCLN3
Associated DiseasesCancer, Cln3 Disease, Ms, neurodegeneration
KG Connections65 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (9)

Astrocytes
cell · KG edge: therapeutic_target
Astrocytes
entity · KG edge: therapeutic_target
ATG10 Gene
gene · KG edge: expressed_in
C1QA Gene
gene · KG edge: therapeutic_target
CXCL10 - C-X-C Motif Chemokine Ligand 10
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CLN3 expressed_in GABARAPL2
CLN3 expressed_in SNX2
CLN3 expressed_in ATG10
CLN3 expressed_in WIPI2
CLN3 therapeutic_target CXCL10
CLN3 therapeutic_target C1QA
CLN3 therapeutic_target TAU
CLN3 therapeutic_target DRD1
CLN3 biomarker_for GPNMB
CLN3 therapeutic_target NLRP3

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