gene

SRSF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRSF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

5Outgoing

12Incoming

0Experiments

0Debates

Summary

Serine/arginine-rich splicing factor 2 - splicing gene

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🧬 Gene Info

Gene Symbol	SRSF2
Aliases	Serine/arginine-rich splicing factor 2
Chromosome	17q25.2
Protein Type	Gene
Function	SRSF2 encodes serine/arginine-rich splicing factor 2 (SC35), a member of the SR family of splicing factors.
Primary Expression	all tissues
Subcellular Localization	, RNA-binding properties, and protein interactions. This post-translational modification is essential for cycling betwee
Molecular Weight	25 kDa
Amino Acids	248 aa
UniProt ID	P84103
GeneCards	SRSF2
Human Protein Atlas	SRSF2
Associated Diseases	ALS
Interactions	ASXL1, BRAF, DNMT3A, RAS, RNA, SRPK1
KG Connections	17 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SRSF2 — AlphaFold P84103 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SRSF2 Gene

gene · 548 words

→

SRSF2 Protein

protein · 617 words

→

Pathway Diagram

graph TD
    SRSF2["SRSF2
Serine/Arginine-rich
Splicing Factor 2"]
    SRPK1["SRPK1
SRSF Protein Kinase 1"]
    CLK1["CLK1
CDC-like Kinase 1"]
    
    PRE_MRNA["Pre-mRNA
Substrates"]
    SPLICING["Alternative
Splicing"]
    MATURE_MRNA["Mature mRNA
Isoforms"]
    
    NEURONAL_MRNA["Neuronal-specific
mRNA Processing"]
    SYNAPTIC_PROTEINS["Synaptic Protein
Expression"]
    NEURONAL_FUNCTION["Neuronal Function
and Connectivity"]
    
    SPLICING_DYSREG["Splicing
Dysregulation"]
    ABERRANT_ISOFORMS["Aberrant Protein
Isoforms"]
    NEURONAL_STRESS["Neuronal
Stress"]
    NEURODEGENERATION["Neurodegeneration
and Cell Death"]
    
    ALS_FTD["ALS/FTD
Pathology"]
    PROTEIN_AGGREGATES["Protein
Aggregation"]
    
    SRPK1 -->|"phosphorylates"| SRSF2
    CLK1 -->|"phosphorylates"| SRSF2
    
    PRE_MRNA --> SPLICING
    SRSF2 -->|"regulates"| SPLICING
    SPLICING --> MATURE_MRNA
    
    MATURE_MRNA --> NEURONAL_MRNA
    NEURONAL_MRNA --> SYNAPTIC_PROTEINS
    SYNAPTIC_PROTEINS --> NEURONAL_FUNCTION
    
    SRSF2 -->|"mutations cause"| SPLICING_DYSREG
    SPLICING_DYSREG --> ABERRANT_ISOFORMS
    ABERRANT_ISOFORMS --> NEURONAL_STRESS
    NEURONAL_STRESS --> NEURODEGENERATION
    
    NEURODEGENERATION --> ALS_FTD
    ABERRANT_ISOFORMS --> PROTEIN_AGGREGATES
    PROTEIN_AGGREGATES --> NEURODEGENERATION
    
    style SRSF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style NEURONAL_FUNCTION fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style SYNAPTIC_PROTEINS fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style SPLICING_DYSREG fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style NEURODEGENERATION fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style PROTEIN_AGGREGATES fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style SRPK1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style CLK1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style ALS_FTD fill:#3a2a1a,stroke:#ffa726,stroke-width:2px

Outgoing (5)

Target	Relation	Type	Str
BRAF	interacts_with	gene	0.75
TET2	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
SRSF3	associated_with	gene	0.60
SRSF3	co_expressed_with	gene	0.50

Incoming (12)

Source	Relation	Type	Str
RAS	interacts_with	gene	0.60
RNA	regulates	gene	0.60
RNA	interacts_with	gene	0.60
ASXL1	interacts_with	gene	0.60
DNMT3A	interacts_with	gene	0.60
HNRNPA1	associated_with	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
SRSF1	associated_with	gene	0.60
SRPK1	phosphorylates	gene	0.55
SRSF1	phosphorylates	gene	0.55
HNRNPA2B1	co_expressed_with	gene	0.50
SRSF1	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SRSF2 in their description or question text

No additional research found