| Gene Symbol | BACE2 |
| Full Name | Beta-Secretase 2 |
| Chromosome | 21q22.3 |
| Protein Type | Protease |
| Function | BACE2 is a member of the aspartyl protease family and shares 64% sequence homology with BACE1. |
| Primary Expression | various tissues including brain, pancreas, and heart |
| Amino Acids | 518 aa |
| Pathways | Notch |
| UniProt ID | Q15120 |
| Ensembl ID | ENSG00000182240 |
| GeneCards | BACE2 |
| Human Protein Atlas | BACE2 |
| BACE1 Gene | Homologous protease with dominant role in amyloid-beta generation |
| Amyloid Precursor Protein (APP) | Primary substrate shared with BACE1 |
| Neuregulin-1 | BACE2-cleaved growth factor crucial for neuronal survival |
| Associated Diseases | Als, Alzheimer |
| Interactions | AD, APOE, APP, AΒ, BACE1, CHAT |
| KG Connections | 61 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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