protein 1,206 words KG: TRAIL
Contents

TRAIL (TNF-Related Apoptosis-Inducing Ligand) Protein

🔬 Protein Info
Gene SymbolTNFSF10
AliasesTNF-Related Apoptosis-Inducing Ligand
Chromosome3q26
Functionis a type II transmembrane protein belonging to the TNF superfamily.
Primary Expressionbrain cells of Alzheimer's disease patients at significantly elevated levels compared to age-matched controls
Molecular Weight32.5 kDa (monomer), ~97.5 kDa (homotrimer)
Amino Acids281 aa
PathwaysAkt, Apoptosis, ER stress, Glycolysis, Mapk
UniProt IDP50591
GeneCardsTNFSF10
Human Protein AtlasTNFSF10
Associated DiseasesALS, traumatic brain injury, TUMOR
InteractionsActin, AKT1, AMPK, AND, APOPTOSIS, App
KG Connections113 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.92
SASP-Mediated Complement Cascade Amplification
Score: 0.91

Related Analyses (15)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates
IFNG Gene
gene · KG edge: activates
Genes
index · KG edge: inhibits
EGF Gene
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

RIPK1 activates TRAIL
JUN activates TRAIL
IFNG inhibits TRAIL
TRAIL activates RIPK1
TRAF6 activates TRAIL
JNK activates TRAIL
AKT1 activates TRAIL
EGFR activates TRAIL
EGF activates TRAIL
IRF3 activates TRAIL

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