Contents

TAAR1 — Trace Amine-Associated Receptor 1

🧬 Gene Info

Gene Symbol	TAAR1
Full Name	Trace Amine-Associated Receptor 1
Chromosome	12
Protein Type	Gene
Function	is a G-protein-coupled receptor (GPCR) that responds to endogenous trace amines, including tyramine, β-phenylethylamine (PEA), and tryptamine[@gainetdinov2004].
Primary Expression	both neurons and glial cells
Amino Acids	339 aa
Pathways	Mitochondrial Function
GeneCards	TAAR1
Human Protein Atlas	TAAR1
β-Phenylethylamine (PEA)	Often called "endogenous amphetamine," PEA is the most potent endogenous trace amine for TAAR1[@gainetdinov2004]
Tyramine	Present in the brain at low concentrations, tyramine activates TAAR1 and competes with PEA binding[@diller2001]
Tryptamine	A minor endogenous ligand with lower potency[@gainetdinov2004]
3-Iodothyronamine (T1AM)	A thyroid hormone derivative that potently activates TAAR1, producing novel central nervous system effects[@zucchi2006]
Olfactory System	High expression in the olfactory bulb and piriform cortex, suggesting a role in olfactory processing[@snel2014]
Associated Diseases	ALS, Cardiomyopathy, Inflammation, Lymphoma, Ms, Retinopathy
Known Drugs/Compounds	rapamycin
Interactions	AADC, Actin, AND, BCL-2, BCL2, BECLIN1
KG Connections	160 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

No AI portrait yet

Knowledge Graph