Contents

TBK1 Protein

🔬 Protein Info

Gene Symbol	TBK1
Full Name	TANK Binding Kinase 1
Chromosome	12q14.2
Protein Type	Serine/Threonine Kinase
Function	TBK1 belongs to the IκB kinase (IKK) subfamily of kinases, originally characterized for its role in activating innate immune signaling through the induction of type I interferons in response to viral
Primary Expression	Motor cortex, Spinal cord, Immune cells
Subcellular Localization	</strong></td><td>Cytoplasm, endosomes, mitochondria</td></tr>
Molecular Weight	84 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Er Stress, Immune Response
UniProt ID	Q9UHD2
NCBI Gene ID	29110
Ensembl ID	ENSG00000183735
OMIM	604834
GeneCards	TBK1
Human Protein Atlas	TBK1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Known Drugs/Compounds	amlexanox, rapamycin
Interactions	Actin, AGING, AIM2, AKT, AKT1, ALS
SciDEX Hypotheses	TBK1 Loss-of-Function Amplifies C1q-Mediated Synap TBK1 Phosphorylation State Creates Phospho-Regulat
KG Connections	1277 knowledge graph edges
Databases	GeneCards HPA STRING

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Knowledge Graph

TBK1 activates ULK1

TBK1 phosphorylates P62_SQSTM1

TBK1 phosphorylates IRF3

SPHK1 activates TBK1

TARDBP activates TBK1

PINK1 activates TBK1

LC3 activates TBK1

MTOR activates TBK1

PTEN activates TBK1