Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CGAS_STING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| TBK1 | activates | protein | 0.72 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY_PATHWAY | inhibits | pathway | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| cGAS-STING Pathway Hyperactivation Mediates Tau Propagation | 0.760 | neurodegeneration | Gap 006 analysis (archived stub) |
| Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific | 0.720 | neurodegeneration | What determines the specificity of TDP-4 |
| cGAS-STING Senescence Circuit Disruption | 0.691 | neurodegeneration | Gene expression changes in aging mouse b |
| Chronic cGAS/STING Hyperactivation Drives Progressive Neurod | 0.661 | neuroinflammation | How does chronic cGAS/STING activation d |
| Astrocyte cGAS/STING Activation Converts Protective into Des | 0.580 | neuroinflammation | How does chronic cGAS/STING activation d |
| Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta | 0.560 | neuroinflammation | How does chronic cGAS/STING activation d |
| Mitochondrial DNA Damage and cGAS-STING Activation Induces M | 0.520 | neurodegeneration | What molecular mechanisms drive microgli |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] | Li D, Cui G, Yang K, Lu C, Jiang Y et al | Nat Cell Biol | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] | Li L, Ye Q, Ma J, Wang Z, Liu T et al. | Cancer Cell | 2026 | 0 |
| DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251] | Tomaskovic I, Prieto-Garcia C, Boskovic | Science | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243] | Zhang M, Lan Y, Yue Q, He J, Li L et al. | J Nanobiotechnology | 2026 | 0 |
| STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053] | Ye R, Wang S, Hu Y, Pan Y, Zheng W et al | Science | 2026 | 0 |
| APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164] | Unknown | 2025 | 0 | |
| The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238] | Unknown | 2025 | 0 | |
| Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133] | Hyde VR, Zhou C, Fernandez JR, Chatterje | Cell reports | 2025 | 0 |
| Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433] | Carling GK, Fan L, Foxe NR, Norman K, Wo | Neuron | 2024 | 0 |
| Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623] | ["Jin Meihua", "Shiwaku Hiroki", "Tanaka | Nature communications | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CGAS_STING in their description or question text
Score: 0.560 · neuroinflammation · 2026-04-21
## Mechanistic Overview Temporal cGAS-STING Activation Stage-Specific Therapeutic Targeting starts from the claim that m
Score: 0.520 · neurodegeneration · 2026-04-22
## Mechanistic Overview Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence starts from the