| Gene Symbol | MDH1 |
| Full Name | Malate Dehydrogenase 1 |
| Chromosome | 2p13.3 |
| Protein Type | Enzyme |
| Function | is a cytosolic enzyme that catalyzes the reversible conversion of malate to oxaloacetate using NAD⁺/NADH as cofactors[@minarik2002]. |
| Primary Expression | all tissues: |
| Amino Acids | 334 aa |
| Exons | 9 |
| Ensembl ID | ENSG00000070785 |
| GeneCards | MDH1 |
| Human Protein Atlas | MDH1 |
| NAD⁺-binding domain | Rossmann fold for cofactor binding |
| Dimerization domain | Forms active homodimer |
| Active site | Contains catalytic residues for malate/oxaloacetate conversion |
| Cytosolic localization | No mitochondrial targeting sequence |
| Associated Diseases | Als, Alzheimer, Amyotrophic Lateral Sclerosis, disease, Inflammation, Ms |
| Interactions | Aβ, Bdnf, BDNF, Cytokine, CYTOKINES, DMSO |
| KG Connections | 127 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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