protein 2,976 words KG: GSK3B
Contents

GSK3B (Glycogen Synthase Kinase 3 Beta)

🔬 Protein Info
Gene SymbolGSK3B
AliasesGSK-3β, TPKII, Tau tubulin kinase (TTBK)
Chromosome3q13.33
Protein TypeSerine/Threonine Kinase
Functionis a constitutively active serine/threonine kinase encoded by the GSK3B gene that plays central and multifaceted roles in cellular physiology[@woodgett1990].
Molecular Weight47 kDa (420 amino acids)
Amino Acids420 aa
Exons12
PathwaysAkt, Cholesterol, Mapk, Microrna, Nf-Kb
GeneCardsGSK3B
Human Protein AtlasGSK3B
Associated DiseasesAging, ALS, Alzheimer, Alzheimer's disease, APOPTOSIS
Known Drugs/CompoundsANTHOCYANINS, Ficus deltoidea, LITHIUM, rapamycin, RAPAMYCIN, SB216763
InteractionsABCA1, ACETYL-COA, ACHE, Actin, AD, ADAM17
KG Connections1182 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (33)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
APOE-Dependent Autophagy Restoration
Score: 0.86
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
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Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

See Also (5)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2
gene · KG edge: degrades
ADRB2 Gene
gene · KG edge: interacts_with
AIFM1 Gene
gene · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

C3 regulates GSK3B
TCF4 associated_with GSK3B
MYC associated_with GSK3B
LC3 associated_with GSK3B
MTOR associated_with GSK3B
BECN1 associated_with GSK3B
CTNNB1 associated_with GSK3B
AXIN2 associated_with GSK3B
GAPDH associated_with GSK3B
SQSTM1 associated_with GSK3B

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