gene 1,603 words KG: TIMMDC1
Contents

TIMMDC1 — Translocase of Inner Mitochondrial Membrane Domain Containing 1

🧬 Gene Info
Gene SymbolTIMMDC1
Full NameTranslocase of Inner Mitochondrial Membrane Domain Containing 1
Chromosome3q21.3
Functionis a critical mitochondrial assembly factor essential for the proper formation and stabilization of respiratory Complex I (NADH:ubiquinone oxidoreductase).
Subcellular Localizationthe mitochondrial inner membrane, where it functions as a non-catalytic assembly factor. TIMMDC1 belongs to the mitochon
Amino Acids299 aa
Exons12
PathwaysEffect
Ensembl IDENSG00000109684
GeneCardsTIMMDC1
Human Protein AtlasTIMMDC1
Associated DiseasesAls, Cardiomyopathy, Cardiovascular, Inflammation
KG Connections41 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

APOE-Dependent Autophagy Restoration
Score: 0.88
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
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Related Analyses (15)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Mitochondria
entity · KG edge: associated_with
Genes
index · KG edge: associated_with
BCS1L Gene
gene · KG edge: associated_with
CD14 — CD14 Molecule
gene · KG edge: associated_with
FBXO7 — F-Box Protein 7
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TIMMDC1 therapeutic_target CD14
TIMMDC1 associated_with FBXO7
TIMMDC1 associated_with LYRM7
TIMMDC1 associated_with BCS1L
TIMMDC1 biomarker_for Septic Cardiomyopathy
CD14 therapeutic_target TIMMDC1
TIMMDC1 associated_with CD14
FBXO7 associated_with TIMMDC1
LYRM7 associated_with TIMMDC1
BCS1L associated_with TIMMDC1

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