Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PDH |
| Key Genes/Proteins | DNM1L, DRP1, HIF, HK2, KEAP1, LC3 |
| Related Pathways | autophagy pathway |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
PDH[PDH]
PDH -->|activates| PINK1[PINK1]
PDH -->|activates| PRKN[PRKN]
PDH -->|activates| PTEN[PTEN]
PDH -->|activates| SIRT3[SIRT3]
PDH -->|participates in| autophagy_pathway[autophagy pathway]
PDH -->|participates in| ubiquitin_proteasome[ubiquitin-proteasome]
PDH -->|expressed in| neurons[neurons]
PDH -->|data_in| benchmark_ot_ad_answer_key_PDH[benchmark_ot_ad_answer_key:PDH]
PAL[PAL] -->|upregulates| PDH
DNM1L[DNM1L] -->|activates| PDH
DRP1[DRP1] -->|activates| PDH
KEAP1[KEAP1] -->|activates| PDH
LC3[LC3] -->|activates| PDH
MFN1[MFN1] -->|activates| PDH
OPA1[OPA1] -->|activates| PDH
HK2[HK2] -->|activates| PDH
MAP1LC3[MAP1LC3] -->|activates| PDH
HIF[HIF] -->|activates| PDH| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PDH | data_in | dataset_row | 0.00 |
| SIRT3 | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PDH | data_in | dataset_row | 0.00 |
| PAL | upregulates | compound | 0.80 |
| DNM1L | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| KEAP1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MFN1 | activates | gene | 0.60 |
| OPA1 | activates | gene | 0.60 |
| HIF | activates | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| LDHA | activates | gene | 0.60 |
| MCT1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Rescue PDH Activation (H5): Indirect Lipogenesis S | 0.550 | neurodegeneration | Does restoring neuronal AMPK activity re |
| Metabolic Reprogramming Toward GAPDH Inhibition | 0.450 | neurodegeneration | How does controlled lysosomal membrane p |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PDH in their description or question text
No additional research found