concept

MCT8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MCT8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

0Hypotheses

0Analyses

50Outgoing

14Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MCT8
Key Genes/Proteins	AGING, App, ASTROCYTES, BASIGIN
Related Diseases	Aging, Allan-Herndon-Dudley syndrome, Allan-Herndon-Dudley Syndrome, Als, Anxiety
Related Pathways	Blood-Brain Barrier

Wiki Pages (1)

Knowledge base pages for this entity

SLC16A2 Gene (MCT8)

gene · 2721 words

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Pathway Diagram

graph TD
    MCT8["MCT8"]
    MCT8 -->|"involved_in"| Thyroid_Hormone_Metabolism["Thyroid Hormone Metabolism"]
    MCT8 -->|"transports"| Thyroid_Hormone["Thyroid Hormone"]
    MCT8 -->|"causes"| Allan_Herndon_Dudley_Syndrome["Allan-Herndon-Dudley Syndrome"]
    MCT8 -->|"regulates"| ASTROCYTE["ASTROCYTE"]
    MCT8 -->|"target for"| Cancer["Cancer"]
    MCT8 -->|"target for"| Aging["Aging"]
    MCT8 -->|"causes"| Als["Als"]
    SLC16A2["SLC16A2"] -->|"encodes"| MCT8
    AGING["AGING"] -->|"target for"| MCT8
    NEURON["NEURON"] -->|"inhibits"| MCT8
    SLC16A10["SLC16A10"] -->|"transports"| MCT8
    SLC16A3["SLC16A3"] -->|"target for"| MCT8

Outgoing (88)

Target	Relation	Type	Str
Thyroid Hormone Metabolism	involved_in	pathway	1.00
ALLAN-HERNDON-DUDLEY SYNDROME	associated_with	entity	0.98
THYROID HORMONE	associated_with	entity	0.95
Thyroid Hormone	transports	compound	0.95
Thyroid Hormone Transport	mediates	process	0.95
Allan-Herndon-Dudley Syndrome	causes	disease	0.95
Cerebral Hypothyroidism	associated_with	phenotype	0.90
Thyroid Hormones	transports	molecule	0.90
NEURODEGENERATION	associated_with	entity	0.90
cerebral hypothyroidism	causes	phenotype	0.90
ASTROCYTE	regulates	entity	0.85
Brain	expressed_in	brain_region	0.85
X-Linked Inheritance	associated_with	mechanism	0.85
Allan-Herndon-Dudley syndrome	therapeutic_target	disease	0.80
oxidative stress response	participates_in	pathway	0.70
neurodegeneration	causes	disease	0.70
neurons	expressed_in	cell_type	0.70
SLC16A2	associated_with	gene	0.70
Als	causes	disease	0.65
Als	associated_with	disease	0.65
Aging	causes	disease	0.65
Als	transports	disease	0.65
Anxiety	transports	disease	0.65
Neurodegeneration	transports	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
RNA	causes	gene	0.60
SLC16A1	associated_with	gene	0.60
SLC16A1	transports	gene	0.60
AGING	therapeutic_target	gene	0.60
RNA	associated_with	gene	0.60
astrocytes	expressed_in	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
SLC16A3	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
hippocampal neurogenesis	involved_in	pathway	0.60
T4	binds_to	drug	0.60
BASIGIN	interacts_with	protein	0.60
blood-brain barrier	participates_in	pathway	0.60
TH	regulates	gene	0.60
SLC16A2	activates	gene	0.60
TH	causes	gene	0.60
stem cells	expressed_in	cell_type	0.60
T3	binds_to	drug	0.60
T3	interacts_with	drug	0.60
thyroid hormone	binds_to	drug	0.60
thyroid hormone resistance	contributes_to	disease	0.60
blood-brain barrier	interacts_with	cell_type	0.60
SLC16A2	transports	gene	0.60

Incoming (14)

Source	Relation	Type	Str
Thyroid Hormone	interacts_with	compound	0.90
SLC16A2	encodes	gene	0.60
SLC16A10	associated_with	gene	0.60
SLC16A2	associated_with	gene	0.60
AGING	therapeutic_target	gene	0.60
SLC16A1	transports	gene	0.60
SLC16A10	transports	gene	0.60
SLC16A3	therapeutic_target	gene	0.60
SLC16A2	transports	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
RNA	causes	gene	0.60
SLC16A2	causes	gene	0.60
SLC16A2	regulates	gene	0.60
NEURON	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MCT8 in their description or question text

No additional research found