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gene 2,721 words KG: SLC16A2
Contents

SLC16A2 Gene (MCT8)

🧬 Gene Info
Gene SymbolSLC16A2
Full NameMonocarboxylate transporter 8
Protein Familytransporter
Target ClassTransporter
Mechanism of ActionSubstrate supplementation or transporter modulation
DruggabilityLow (0.39)
Clinical StagePhase I
PathwaysX chromosome, SLC16 family, thyroid function, Blood-Brain Barrier, Lactate/monocarboxylate transport
GeneCardsSLC16A2
Human Protein AtlasSLC16A2
Associated DiseasesAging, ALI, Allan-Herndon-Dudley syndrome, Als, AMI
Known Drugs/CompoundsTriiodothyroacetic acid
InteractionsC1Q, CANCER, CYP2E1, GSS, JUN, MCT8
SciDEX TargetView Target Profile (1 clinical trials)
SciDEX HypothesesAstrocytic Lactate Shuttle Enhancement for Grid Ce
KG Connections165 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (24)

Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53CYP46A1 Overexpression Gene Therapy
Score: 0.92Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Senescent Cell Mitochondrial DNA Release
Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74

Related Analyses (5)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40s:** - Test MCU overexpression specifically in layer II neur
falsification · proposed · Score: 0.40

See Also (8)

Gerstmann-Straussler-Scheinker Syndrome (GSS)
disease · KG edge: activatesGenes
index · KG edge: associated_withATL1
gene · KG edge: associated_withC1QA Gene — Complement Component 1q A Chain
gene · KG edge: activatesCOL4A1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SLC16A2 associated_with neurodegeneration
PPARGC1A co_discussed SLC16A2
SLC16A2 co_discussed RELN
SLC16A2 co_discussed MAP6
SLC16A2 co_discussed HCN1
SLC16A2 co_discussed MCU
SLC16A2 co_discussed IDH2
JUN therapeutic_target SLC16A2
SLC16A2 regulates Astrocytic Lactate Shuttle Enhancement for Grid Ce
SLC16A2 regulates Tau Propagation

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