gene 628 words KG: WRN
Contents

WRN — Werner Syndrome RecQ Like Helicase

🧬 Gene Info
Gene SymbolWRN
Full NameWerner Syndrome RecQ Like Helicase
AliasesPage for WRN Protein
Protein TypeEnzyme
FunctionWRN is a multifunctional DNA metabolic enzyme:
Molecular Weight164 kDa
Ensembl IDENSG00000113240
GeneCardsWRN
Human Protein AtlasWRN
Base excision repair (BER)Processing of oxidative DNA damage
DNA double-strand break repairHomologous recombination and NHEJ
Telomere maintenancePrevents telomere dysfunction
Replication fork restartResolves stalled replication forks
Associated DiseasesAging, Ms, Senescence
InteractionsCOMPLEMENT, CTC1, LMNA, MDM2, MRE11, MUTYH
KG Connections26 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (2)

VCP-Mediated Autophagy Enhancement
Score: 0.59
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (2)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
nad-augmentation-therapy-early-ad
general · KG edge: inhibits
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: interacts_with
ATM Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

TREX1 interacts_with WRN
VCP interacts_with WRN
NEIL1 interacts_with WRN
POLD1 interacts_with WRN
POT1 interacts_with WRN
MRE11 interacts_with WRN
MUTYH interacts_with WRN
SAMHD1 interacts_with WRN
NBS1 interacts_with WRN
LMNA interacts_with WRN

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