gene 603 words KG: TRAF6
Contents

TRAF6 Gene

🧬 Gene Info
Gene SymbolTRAF6
Chromosome11p12
Protein TypeGene
FunctionTRAF6 is a central signaling molecule in multiple pathways
Molecular Weight60 kDa
Amino Acids524 aa
PathwaysNF-κB signaling, NF-κB, MAPK
GeneCardsTRAF6
Human Protein AtlasTRAF6
Associated DiseasesAls, Atherosclerosis, Autoimmune, Cancer, Encephalitis, Inflammation
Known Drugs/Compoundsrapamycin
InteractionsACVR1, AD, AKT, AKT1, AMPK, AND
KG Connections669 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (12)

Astrocytes
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Astrocytes
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACVR1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TRAF6 associated_with MTOR
TRAF6 associated_with CHOP
TRAF6 associated_with NRF2
BAX associated_with TRAF6
FIS1 associated_with TRAF6
TRAF6 associated_with BECLIN1
TRAF6 associated_with BCL2
TRAF6 associated_with TAAR1
TRAF6 associated_with SIGMAR1
TRAF6 associated_with MYD88

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