gene 4,033 words KG: PEN2
Contents

PEN2 Gene

🧬 Gene Info
Gene SymbolPSENEN
AliasesPresenilin Enhancer 2
Chromosome19q13.12
Protein FamilyPEN-2 family (γ-secretase complex)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionEndoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight12 kDa
Amino Acids101 aa
PathwaysAngiogenesis
UniProt IDQ9NQ75
GeneCardsPSENEN
Human Protein AtlasPSENEN
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI
InteractionsA2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE
KG Connections94 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

Glial Glycocalyx Remodeling Therapy
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
← Prevpg 2/2

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
A2M Gene
gene · KG edge: interacts_with
ANG — Angiogenin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NCSTN interacts_with PEN2
FAS interacts_with PEN2
TNF interacts_with PEN2
LMNA interacts_with PEN2
APH1B interacts_with PEN2
APOE interacts_with PEN2
IL6 interacts_with PEN2
SREBF1 interacts_with PEN2
PSEN2 interacts_with PEN2
A2M interacts_with PEN2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.