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protein 655 words KG: NCSTN
Contents

NCSTN Protein

🔬 Protein Info
Gene SymbolNCSTN
AliasesNicastrin
Protein FamilyAnterior pharynx defective (APH) family
FunctionNicastrin functions as part of the gamma-secretase complex which includes: - Presenilin (PSEN1 or PSEN2): The catalytic subunit - Aph-1 (APH1A/B/L): Stabilizes the complex - Pen-2: Required for comple
Subcellular LocalizationEndoplasmic reticulum, Golgi, plasma membrane
Molecular Weight230 kDa
Amino Acids600 aa
PathwaysNotch, Notch signaling
UniProt IDQ9Y5G0
GeneCardsNCSTN
Human Protein AtlasNCSTN
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI
InteractionsA2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE
KG Connections189 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Glial Glycocalyx Remodeling Therapy
Score: 0.65Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: expressed_inAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_withA2M Gene
gene · KG edge: interacts_withABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: degradesadam17
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

NCSTN interacts_with FAS
NCSTN interacts_with TNF
NCSTN interacts_with LMNA
NCSTN interacts_with APH1B
NCSTN interacts_with APOE
NCSTN interacts_with IL6
NCSTN interacts_with SREBF1
NCSTN interacts_with A2M
NCSTN interacts_with DHCR24
NCSTN interacts_with HMGCR

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