gene 2,724 words KG: PDK4
Contents

PDK4 (3-Phosphoinositide-Dependent Protein Kinase-4)

🧬 Gene Info
Gene SymbolPDK4
Chromosome7q21.3
Protein TypeKinase
Functionis a member of the phosphoinositide-dependent protein kinase (PDK) family that plays critical roles in regulating cellular metabolism, mitochondrial function, and survival.
Primary Expressiontissues with high metabolic demand, including heart, skeletal muscle, and brain
Amino Acids404 aa
Exons10
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
Ensembl IDENSG00000101447
GeneCardsPDK4
Human Protein AtlasPDK4
Associated DiseasesMs
InteractionsFERROPTOSIS, UBIQUITIN
KG Connections94 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
← Prevpg 2/2

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
Genes
index · KG edge: regulates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates
BAX Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SOD2 associated_with PDK4
CAT associated_with PDK4
BAX associated_with PDK4
SPR associated_with PDK4
PPARGC1A associated_with PDK4
CASP3 associated_with PDK4
PDK1 associated_with PDK4
PDK4 associated_with SOD1
PDK4 associated_with TNFR2
PDK4 associated_with BCL2

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