| Gene Symbol | NSD2 |
| Full Name | Nuclear Receptor Binding SET Domain Protein 2 |
| Chromosome | 4p16.3 |
| Protein Type | Transferase |
| Function | encodes a histone lysine methyltransferase of the NSD family that catalyzes dimethylation of histone H3 at lysine 36 (H3K36me2). |
| Amino Acids | 1365 aa |
| Pathways | Cholesterol |
| UniProt ID | [O96028](https://www.uniprot.org/uniprot/O96028) |
| Ensembl ID | ENSG00000109685 |
| GeneCards | NSD2 |
| Human Protein Atlas | NSD2 |
| SET domain | The catalytic methyltransferase domain that specifically dimethylates H3K36 |
| PWWP domain | Reads existing H3K36 methylation marks, enabling processive methylation along gene bodies |
| PHD fingers (4x) | Recognize various histone tail modifications for chromatin context-dependent activity |
| HMG box | Provides non-sequence-specific DNA binding capability |
| Associated Diseases | Als, Hepatitis, Lymphoma |
| Interactions | AND, CDKN2A, DNA, ERN1, KMT2D, MYC |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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