| Gene Symbol | NFAT5 |
| Full Name | Nuclear Factor of Activated T Cells 5 |
| Protein Type | Transcription Factor |
| Function | NFAT5 (Nuclear Factor of Activated T Cells 5), also known as TonEBP (Tonicity-Responsive Enhancer Binding Protein), is a transcription factor that plays crucial roles in cellular stress responses. |
| Primary Expression | neurons, astrocytes, and microglia, where it contributes to: [@biomarkers2016] - Hippocampal synaptic plasticity - Astrocyte responses to injury - Mic |
| Pathways | Mapk |
| GeneCards | NFAT5 |
| Human Protein Atlas | NFAT5 |
| Osmoprotection | Regulates expression of osmolyte transporters and synthesis enzymes |
| Immune response | Controls cytokine expression in immune cells |
| Neuroprotection | Mediates cellular responses to metabolic and oxidative stress in neurons |
| Inflammation | Regulates expression of pro-inflammatory mediators in microglia and astrocytes [2] |
| Brain | Expressed in neurons (especially hippocampus), astrocytes, and microglia |
| Regional Distribution | High expression in hippocampus, cortex, and hypothalamus |
| Upregulation | Strongly induced by osmotic stress, inflammation, and neuronal injury |
| Associated Diseases | Carcinoma |
| Interactions | AND, CANCER, CD4, CYTOKINES, GENES, JUN |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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