gene 2,350 words KG: RRAGA
Contents

RRAGA — Ras-Related GTP Binding A

🧬 Gene Info
Gene SymbolRRAGA
Full NameRas-Related GTP Binding A
Chromosome9p21.1
Functionis a member of the Rag GTPase family that plays a central role in regulating the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway<sup>[1]</sup>.
PathwaysmTOR, mtor
UniProt ID[Q9Y282](https://www.uniprot.org/uniprot/Q9Y282)
Ensembl IDENSG00000136996
OMIM608456
GeneCardsRRAGA
Human Protein AtlasRRAGA
GxxxxGKST motifPhosphate-binding loop (P-loop) for nucleotide binding
NKXD motifSpecific to GTPases, involved in GDP/GTP binding
Switch I regionUndergoes conformational changes between GDP/GTP states
Switch II regionCritical for effector interactions
C-terminal regionMediates dimerization with RagC/D
Associated DiseasesCancer, Carcinoma
InteractionsAND, ATF4, ATG, ATG8, AUTOPHAGY, CANCER
KG Connections60 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (8)

APOE-Dependent Autophagy Restoration
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Lysosomal Positioning Dynamics Modulation
Score: 0.69

Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with
ATF4 Gene
gene · KG edge: interacts_with
EIF2A Gene
gene · KG edge: interacts_with
FMR1 — Fragile X Messenger Ribonucleoprotein 1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

GABARAP interacts_with RRAGA
ATF4 interacts_with RRAGA
FMR1 interacts_with RRAGA
MTOR interacts_with RRAGA
RRAGA interacts_with G3BP1
RRAGA interacts_with JUN
RRAGA interacts_with MAPT
RRAGA interacts_with RRAGB
RRAGA interacts_with TIA1
RRAGA interacts_with EIF2A

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)