gene 2,260 words KG: MS4A6A
Contents

MS4A6A Gene

🧬 Gene Info
Gene SymbolMS4A6A
Full NameMembrane Spanning 4-Domains A6A
Chromosome11q12.2
FunctionMembrane Protein Function: MS4A6A operates as a membrane receptor or scavenger receptor involved in cellular homeostasis
Primary ExpressionMicroglia, B-cells, Myeloid cells
Molecular Weight28 kDa
Amino Acids243 aa
Exons6
UniProt IDQ9H5Z1
NCBI Gene ID64231
Ensembl IDENSG00000110079
GeneCardsMS4A6A
Human Protein AtlasMS4A6A
Associated DiseasesAls, Alzheimer, GLIOBLASTOMA
InteractionsABCA7, APOE, BIN1, CD2AP, CD33, CD36
KG Connections204 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
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Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

ABCA7 (Redirect)
redirect · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: associated_with
ATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ABCA7 associated_with MS4A6A
APP associated_with MS4A6A
ATP13A2 associated_with MS4A6A
C9ORF72 associated_with MS4A6A
CD33 associated_with MS4A6A
CLU associated_with MS4A6A
FUS associated_with MS4A6A
GBA associated_with MS4A6A
LRRK2 associated_with MS4A6A
MAPT associated_with MS4A6A

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