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Ai_Tool: Evo 2 (Arc Institute / NVIDIA / Stanford)
ai_tool
487 words
KG: MAPT
Contents
Evo 2 (Arc Institute / NVIDIA / Stanford)
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Knowledge Graph
Related Hypotheses (27)
Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.82
Excitatory Neuron Synaptic Dysfunction and Mitochondrial Str
Score: 0.79
Dual-Circuit Tau Vulnerability Cascade
Score: 0.75
Cholinergic Basal Forebrain-Hippocampal Circuit Protection
Score: 0.74
Tau missorting transitions into an autonomous tau-seeding st
Score: 0.74
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio
Score: 0.74
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Rece
Score: 0.74
Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in
Score: 0.73
Microglial Exosome-Mediated Tau Propagation
Score: 0.70
Dual-Circuit Tau Vulnerability Cascade with Glial-Mediated A
Score: 0.70
Selective Tau Kinase Inhibition in Vulnerable Neuronal Subty
Score: 0.68
Microglial TREM2-Mediated Tau Phagocytosis Impairment
Score: 0.68
Fyn-anchored dendritic tau/NMDAR signaling persists after tr
Score: 0.67
Glymphatic-Cholinergic Tau Clearance Cascade
Score: 0.67
Locus Coeruleus-Hippocampal Circuit Protection
Score: 0.65
Rutin stabilizes a non-nucleating tau conformer through dire
Score: 0.63
ATF4-DDIT3 stress signaling indirectly represses MAPT transc
Score: 0.62
Tau Cross-Seeding and Interaction
Score: 0.61
Rutin reduces ROS- and metal-driven tau oligomer nucleation
Score: 0.60
HSF1 reprioritizes transcription and suppresses MAPT while r
Score: 0.60
A post-trigger CDK5-dominant kinase feedback loop maintains
Score: 0.59
Dendritic tau missorting persists through local proteostatic
Score: 0.53
High baseline tau and ISR activation may lower the effective
Score: 0.51
REST-like neuronal silencing programs suppress MAPT in sever
Score: 0.51
Reactive astrocyte glutamate-handling failure sustains dendr
Score: 0.49
BIN1-dependent trafficking defects determine whether post-Aβ
Score: 0.46
Direct cystatin C inhibition of tau aggregation
Score: 0.39
Show 22 more
Related Analyses (5)
Cas13 gRNA Design for Silencing MAPT (Tau) Transcripts in Al
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · completed
Related Experiments (5)
Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90
Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90
Microtubule domain analysis in adult axons
exploratory · proposed · Score: 0.80
Tau depletion effects on microtubule domains in adult axons
exploratory · proposed · Score: 0.80
Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40
Knowledge Graph (12 edges)
MAPT
encodes
TAU
MAPT
associated_with
MAP6
NCSTN
interacts_with
MAPT
FAS
interacts_with
MAPT
TNF
interacts_with
MAPT
LMNA
interacts_with
MAPT
APH1B
interacts_with
MAPT
APOE
activates
MAPT
IL6
interacts_with
MAPT
SREBF1
activates
MAPT
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