gene

RNF8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

4Outgoing

2Incoming

0Experiments

0Debates

Summary

RNF8 - Gene

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🧬 Gene Info

Gene Symbol	RNF8
Aliases	Page for RNF8
Chromosome	6p21.1
Protein Type	Ligase
Function	Recognition: Following DSB formation, ATM kinase phosphorylates histone H2AX (generating γ-H2AX), which serves as a platform for recruiting additional repair proteins [1].
UniProt ID	Q9UPW4
NCBI Gene ID	9027
Ensembl ID	ENSG00000137243
OMIM	611685
GeneCards	RNF8
Human Protein Atlas	RNF8
Associated Diseases	neurodegeneration
Interactions	ATM, BRCA1, CANCER, MDC1
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RNF8 — AlphaFold Q9UPW4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RNF8 - Gene

gene · 940 words

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Pathway Diagram

graph TD
    RNF8["RNF8"]
    Als{"Als"}
    RNF8 -->|"interacts with"| Als
    Cancer{"Cancer"}
    RNF8 -->|"interacts with"| Cancer
    ATM["ATM"]
    RNF8 -->|"activates"| ATM
    MDC1["MDC1"]
    RNF8 -->|"interacts with"| MDC1
    neurodegeneration["neurodegeneration"]
    RNF8 -->|"implicated in"| neurodegeneration
    CANCER["CANCER"]
    CANCER -->|"interacts with"| RNF8
    BRCA1["BRCA1"]
    BRCA1 -->|"interacts with"| RNF8
    style RNF8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
ATM	activates	gene	0.60
MDC1	interacts_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
BRCA1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RNF8 in their description or question text

No additional research found