gene 1,939 words KG: SHH
Contents

SHH — Sonic Hedgehog

🧬 Gene Info
Gene SymbolSHH
Full NameSonic Hedgehog
Chromosome7q36.3
Functionis a pivotal signaling molecule that plays fundamental roles in embryonic development, tissue patterning, and adult tissue homeostasis.
Primary ExpressionSubstantia nigra, Cerebellum, Cortex, Hippocampus, Developing brain, Adult neural stem cells
Molecular Weight19 kDa
Amino Acids462 aa
PathwaysDifferentiation, Hedgehog, Sonic Hedgehog, Wnt
UniProt IDQ15465
NCBI Gene ID6469
Ensembl IDENSG00000164690
OMIM600725
GeneCardsSHH
Human Protein AtlasSHH
Associated DiseasesAging, ALS, Alzheimer, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Cancer
InteractionsADCY3, AKT, ASTROCYTE, ASTROCYTES, ATXN3, CANCER
KG Connections241 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63

Related Analyses (2)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment
clinical · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: activates
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: therapeutic_target
Astrocytes
entity · KG edge: associated_with
ADCY3 — Adenylate Cyclase 3
gene · KG edge: activates

Knowledge Graph (12 edges)

PI3K activates SHH
AKT activates SHH
SHH therapeutic_target P38
SHH therapeutic_target JUN
SHH interacts_with GBM
IL6 activates SHH
RANKL activates SHH
SHH activates MAOA
HDAC6 associated_with SHH
GDNF activates SHH

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.