gene 689 words KG: JUN
Contents

JUN Gene

🧬 Gene Info
Gene SymbolJUN
Full NameJun Proto-Oncogene, AP-1 Transcription Factor Subunit
Chromosome1p32.1
Protein TypeTranscription Factor
Functionc-Jun/AP-1 is a key transcription factor
Primary Expressionproliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain
PathwaysAkt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP45985
NCBI Gene ID3715
Ensembl IDENSG00000100994
OMIM165160
GeneCardsJUN
Human Protein AtlasJUN
Associated DiseasesAddiction, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsanti-CD3, burn serum, pokeweed mitogen, quercetin
InteractionsABCA1, ABCB1, ACSL5, ACTB, Actin, AGING
KG Connections2425 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (59)

Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.59
VCP-Mediated Autophagy Enhancement
Score: 0.59
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Cryptic Exon Silencing Restoration
Score: 0.53
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
← Prevpg 3/3

Related Analyses (10)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90

See Also (7)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

JUN contributes_to AP1
JUN therapeutic_target SLC16A2
JUN protects_against APOE
JUN protects_against RELN
JUN regulates DAB1
JUN regulates FYN
JUN regulates SRC
JUN inhibits HCN1
JUN inhibits HCN4
JUN inhibits HCN2

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