gene 689 words KG: JUN
Contents

JUN Gene

🧬 Gene Info
Gene SymbolJUN
Full NameJun Proto-Oncogene, AP-1 Transcription Factor Subunit
Chromosome1p32.1
Protein TypeTranscription Factor
Functionc-Jun/AP-1 is a key transcription factor
Primary Expressionproliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain
PathwaysAkt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP45985
NCBI Gene ID3715
Ensembl IDENSG00000100994
OMIM165160
GeneCardsJUN
Human Protein AtlasJUN
Associated DiseasesAddiction, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsanti-CD3, burn serum, pokeweed mitogen, quercetin
InteractionsABCA1, ABCB1, ACSL5, ACTB, Actin, AGING
KG Connections2425 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (59)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
← Prevpg 2/3Next →

Related Analyses (10)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90

See Also (7)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

JUN contributes_to AP1
JUN therapeutic_target SLC16A2
JUN protects_against APOE
JUN protects_against RELN
JUN regulates DAB1
JUN regulates FYN
JUN regulates SRC
JUN inhibits HCN1
JUN inhibits HCN4
JUN inhibits HCN2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.