gene 1,167 words KG: GLB1
Contents

GLB1 Gene

🧬 Gene Info
Gene SymbolGLB1
AliasesGLB1 encodes beta-galactosidase, a lysosomal hydrolase. Deficiency causes GM1 gangliosidosis and Morquio B disease
Functionis a 677-amino acid glycoprotein that
Amino Acids677 aa
PathwaysMtor, Mitophagy, Akt
Ensembl IDENSG00000123983
GeneCardsGLB1
Human Protein AtlasGLB1
Highest activityLiver, spleen, brain, kidney
Brain regionsHigh expression in cortex, hippocampus, basal ganglia
Associated DiseasesAlzheimer, Rheumatoid Arthritis, Senescence, Tumor
Known Drugs/Compoundsrapamycin
InteractionsACTB, AKT, AMPK, ATG, ATG5, AURKB
KG Connections125 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
APOE-Dependent Autophagy Restoration
Score: 0.88
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Oligodendrocyte White Matter Vulnerability
Score: 0.65

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
TNF (Redirect)
redirect · KG edge: associated_with
Tumor Necrosis Factor (TNF)
entity · KG edge: associated_with
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: associated_with
CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

OPTINEURIN associated_with GLB1
CDKN1A associated_with GLB1
CDKN2A associated_with GLB1
NDP52 associated_with GLB1
AKT associated_with GLB1
TNF associated_with GLB1
MTOR associated_with GLB1
CALCOCO2 associated_with GLB1
CXCL1 associated_with GLB1
UBIQUITIN associated_with GLB1

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