gene 2,316 words KG: FLT1
Contents

FLT1 Gene

🧬 Gene Info
Gene SymbolFLT1
Full NameFms Related Receptor Tyrosine Kinase 1 (VEGF Receptor 1)
AliasesVEGF Receptor 1
Chromosome13q12.3
Protein TypeReceptor
FunctionThe first three Ig domains are sufficient for VEGF binding, while domains 2-3 are critical for high-affinity interactions.
Molecular Weight180 kDa
PathwaysAngiogenesis, Erk Signaling, Mapk, epigenetic regulation, oxidative stress response
UniProt IDP17948
NCBI Gene ID2321
Ensembl IDENSG00000102755
OMIM165040
GeneCardsFLT1
Human Protein AtlasFLT1
Associated Diseasesneurodegeneration
InteractionsALZHEIMER, AMYLOID, AND, ASTROCYTES, ENO1, ERK
KG Connections81 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Retinal Vascular Microcirculation Rescue
Score: 0.72
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Astrocytes
cell · KG edge: activates
Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Astrocytes
entity · KG edge: activates
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: biomarker_for

Knowledge Graph (12 edges)

ENO1 interacts_with FLT1
DNAJA1 biomarker_for FLT1
HSPA1A interacts_with FLT1
FLT1 interacts_with HSPA8
FLT1 biomarker_for GPX4
FLT1 co_discussed IL1B
FLT1 activates PVALB
TAU inhibits FLT1
TAU activates FLT1
FLT1 activates IL1B

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