gene 791 words KG: HSPA6
Contents

HSPA6

🧬 Gene Info
Gene SymbolHSPA6
Protein TypeChaperone
FunctionHSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) is a member of the Hsp70 family of molecular chaperones.
Primary Expressionvarious cancers:
PathwaysApoptosis, Unfolded Protein Response, Nf-Κb, Phagocytosis
Ensembl IDENSG00000173110
GeneCardsHSPA6
Human Protein AtlasHSPA6
Associated Diseasesneurodegeneration
KG Connections36 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.55
Cryptic Exon Silencing Restoration
Score: 0.53
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Genes
index · KG edge: expressed_in
BAG3 Gene
gene · KG edge: expressed_in
DNAJB1 Gene
gene · KG edge: expressed_in
DNAJC10 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

UBIQUITIN expressed_in HSPA6
BAG3 expressed_in HSPA6
UBC expressed_in HSPA6
HSPD1 expressed_in HSPA6
DNAJC7 expressed_in HSPA6
HSPA6 expressed_in DNAJB1
HSPA6 expressed_in IKBKB
HSPA6 expressed_in HSPA1B
HSPA6 expressed_in HSPE1
HSPA6 expressed_in HSP90AB1

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