| Gene Symbol | CTCF |
| Full Name | CCCTC-Binding Factor |
| Chromosome | 16q22.1 |
| Function | The CTCF gene encodes CCCTC-Binding Factor, a highly conserved zinc finger transcription factor that is one of the most important architectural proteins in the mammalian genome. |
| Primary Expression | both excitatory and inhibitory neurons throughout development and in adulthood |
| Molecular Weight | 83 kDa |
| Pathways | Autophagy, Cell Cycle, Epigenetic, Inflammasome, Neurogenesis |
| UniProt ID | P49711 |
| NCBI Gene ID | 1065 |
| Ensembl ID | ENSG00000102974 |
| OMIM | 114167 |
| GeneCards | CTCF |
| Human Protein Atlas | CTCF |
| Amyotrophic Lateral Sclerosis (ALS) | Altered CTCF binding and chromatin architecture have been reported in ALS, potentially affecting expression of RNA metabolism genes. |
| Huntington's Disease (HD) | CTCF function may be impaired by mutant huntingtin, leading to dysregulation of transcriptional programs. |
| Associated Diseases | Cancer |
| Interactions | ANXIETY, BDNF, BNIP3L, CANCER, DNA, E2F3 |
| KG Connections | 77 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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