gene 1,741 words KG: PRKAB1
Contents

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

🧬 Gene Info
Gene SymbolPRKAB1
Full NameProtein Kinase AMP-Activated Non-Catalytic Subunit Beta 1[@jeon2016]
AliasesAMPK beta-1 subunit
Chromosome12q24.31
Functionis a central cellular energy sensor that plays a critical role in regulating energy homeostasis across all eukaryotic cells.
Subcellular LocalizationPRKAB1 (beta-1) is the predominant isoform in most tissues
Molecular Weight30 kDa
Amino Acids270 aa
PathwaysAMPK, AMPK signaling
UniProt IDQ9Y478
NCBI Gene ID5564
Ensembl IDENSG00000111725
OMIM602636
GeneCardsPRKAB1
Human Protein AtlasPRKAB1
Associated Diseasesneurodegeneration
InteractionsAMPK, AND, Ras
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
APOE-Dependent Autophagy Restoration
Score: 0.88
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (13)

Neurodegeneration
disease · KG edge: implicated_in
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Genes
index · KG edge: associated_with
BIN1 — Bridging Integrator 1
gene · KG edge: therapeutic_target
CACNA1E Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

MIR802 regulates PRKAB1
EPAS1 therapeutic_target PRKAB1
CACNG6 therapeutic_target PRKAB1
BIN1 therapeutic_target PRKAB1
CHRNA2 therapeutic_target PRKAB1
CEBPA therapeutic_target PRKAB1
CNR1 therapeutic_target PRKAB1
CTSD therapeutic_target PRKAB1
NME1 therapeutic_target PRKAB1
CACNA1E therapeutic_target PRKAB1

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