| Gene Symbol | TFRC |
| Full Name | Transferrin Receptor 1 |
| Chromosome | 3q29 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake |
| Mechanism of Action | Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake |
| Druggability | Medium (0.47) |
| Clinical Stage | Approved |
| Molecular Weight | 190 kDa |
| Amino Acids | 660 aa |
| Pathways | Akt, Autophagy, Blood-Brain Barrier, Ferroptosis, Pi3K |
| UniProt ID | P02786 |
| NCBI Gene ID | 7037 |
| Ensembl ID | ENSG00000072274 |
| GeneCards | TFRC |
| Human Protein Atlas | TFRC |
| Associated Diseases | Als, ALZHEIMER, Atherosclerosis, Diabetes, Inflammation |
| Known Drugs/Compounds | Adeno-Associated Virus, Antisense Oligonucleotides, rapamycin, resveratrol |
| Interactions | ACSL4, ACTB, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Blood-Brain Barrier SPM Shuttle System Transferrin-Alectinib Conjugation Enhances Blood-B |
| KG Connections | 369 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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