Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOCHONDRIAL_CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| BCL2 | regulates | protein | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| RAB27A-dependent extracellular vesicle engineering for mitoc | 0.674 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Mitochondrial Calcium Buffering Enhancement via MCU Modulati | 0.650 | neurodegeneration | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Rab27a knockdown effects on microglia activation in developing brain | validation | 0.800 | 0.00 | Neonatal mice with dorsal subv | proposed | N/A | |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| AAV-LRRK2 IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV-LRRK2 Gene Therapy IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| s:** - Test MCU overexpression specifically in layer II neurons in hea | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Exercise-BDNF-Mitophagy Biomarker Study in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Ferroptosis Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson' | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| MLCS Quantification in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Wilson Disease Neurodegeneration: Mechanism and Therapeutic Response | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Mitochondrial calcium uptake declines during aging and is directly activated by [PMID:39603237] | Gherardi G, Weiser A, Bermont F, Migliav | Cell Metab | 2025 | 1 |
| Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipoly [PMID:39153480] | LaMoia TE, Hubbard BT, Guerra MT, Nasiri | Cell Metab | 2024 | 1 |
| Tumour extracellular vesicles and particles induce liver metabolic dysfunction. [PMID:37225988] | Wang G, Li J, Bojmar L, Chen H, Li Z, To | Nature | 2023 | 1 |
| Extracellular vesicles in fatty liver promote a metastatic tumor microenvironmen [PMID:37172577] | Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang | Cell Metab | 2023 | 1 |
| Mitochondrial calcium exchange in physiology and disease. [PMID:34698550] | Garbincius JF, Elrod JW | Physiol Rev | 2022 | 1 |
| Rab27a and Rab27b control different steps of the exosome secretion pathway. [PMID:19966785] | Ostrowski M, Carmo NB, Krumeich S, Fange | Nat Cell Biol | 2010 | 1 |
| Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeti [PMID:41805100] | Qin D, Ding W, Wu X, Peng C, Bo Y et al. | Drug Dev Res | 2026 | 0 |
| Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscu [PMID:41841200] | Matias C, Snider PL, Sierra Potchanant E | J Cachexia Sarcopenia Muscle | 2026 | 0 |
| Zn(2+)-Dependent Modulation of the Mitochondrial Ca(2+) Uniporter Underlies Resv [PMID:41932596] | Xing B, Li X, Wang B, Huang L, Wang Q et | Exp Cell Res | 2026 | 0 |
| SERCA2 Dysfunction Drives Vascular Calcification via Coupling with TSPO-MCU at M [PMID:41932666] | Pi S, Liu W, Zhao J, Chen H, Luo X et al | Pharmacol Res | 2026 | 0 |
| Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU [PMID:39921279] | Zhao H, Chen S, Cao N, Wu W, Liu G, Gao | Advanced science (Weinheim, Ba | 2025 | 0 |
| Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylatio [PMID:40712058] | Liu G, Zhang H, Chen S, Gao J, Zhao H, D | Cancer research | 2025 | 0 |
| Case Report: Late-onset primary hemophagocytic lymphohistiocytosis leading to th [PMID:40852732] | ["Rausch J", "Herold S", "Liebh\u00e4use | Frontiers in immunology | 2025 | 0 |
| Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567] | ["Porzuczek J"] | Sensors (Basel, Switzerland) | 2024 | 0 |
| Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure. [PMID:38847080] | Mallaredy V, Roy R, Cheng Z, Thej C, Ben | Circulation research | 2024 | 0 |
| Interruption of p38 [PMID:38481807] | ["Kim S", "Lee J", "Jung J", "Kim G", "Y | International journal of biolo | 2024 | 0 |
| Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to [PMID:35849032] | Liu X, Tan S, Liu H, Jiang J, Wang X, Li | Hepatology (Baltimore, Md.) | 2023 | 0 |
| A vision-based real-time traffic flow monitoring system for road intersections. [PMID:36789012] | ["Azimjonov J", "\u00d6zmen A", "Varan M | Multimedia tools and applicati | 2023 | 0 |
| Mitochondrial calcium cycling in neuronal function and neurodegeneration. [PMID:36760367] | Walters GC, Usachev YM | Frontiers in cell and developm | 2023 | 0 |
| Autophagy and exosomes coordinately mediate quercetin's protective effects on al [PMID:36965782] | ["Chen H", "Liu J", "Peng S", "Yang G", | The Journal of nutritional bio | 2023 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MITOCHONDRIAL_CA in their description or question text
No additional research found