| Gene Symbol | ADAM8 |
| Full Name | A Disintegrin And Metalloproteinase Domain 8 |
| Chromosome | 10q26.3 |
| Function | is a member of the ADAM (A Disintegrin And Metalloproteinase) family of zinc-dependent metalloproteases. |
| Primary Expression | immune cells and in the brain, particularly in microglia, astrocytes, and neurons |
| Amino Acids | 833 aa |
| UniProt ID | [O43506](https://www.uniprot.org/uniprot/O43506) |
| Ensembl ID | ENSG00000151617 |
| GeneCards | ADAM8 |
| Human Protein Atlas | ADAM8 |
| Zinc-binding site | Essential for proteolytic activity |
| Active site | HExGHxxGxxH consensus sequence coordinating zinc ion |
| Substrate-binding groove | Determines substrate specificity |
| Autocatalytic cleavage | Prodomain removal activates the protease |
| Furin-mediated processing | Furin-like convertases in the secretory pathway |
| Associated Diseases | Cancer, Leukemia, Lung Cancer |
| Interactions | ANXA2, APOPTOSIS, AUTOPHAGY, BAX, BAX/BCL2, BCL2 |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!