gene 943 words KG: CHD1
Contents

CHD1 Gene

🧬 Gene Info
Gene SymbolCHD1
Full NameChromodomain Helicase DNA Binding Protein 1
Chromosome5q21.1
Protein TypeATP-dependent chromatin remodeler
Functionis a member of the chromodomain helicase/ATPase (CHD) family of proteins that utilize ATP to remodel chromatin structure [@chd].
Molecular Weight223 kDa
Amino Acids300 aa
PathwaysCholesterol, lipid metabolism
UniProt IDQ86W28
NCBI Gene ID1105
Ensembl IDENSG00000153922
OMIM602118
GeneCardsCHD1
Human Protein AtlasCHD1
Associated DiseasesAging, ALS, Cancer, disease, TUMOR
InteractionsAR, CANCER, SPOP
KG Connections32 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (2)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (3)

ar
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

CHD1 therapeutic_target Rb
AR activates CHD1
CANCER activates CHD1
SREBP2 causes CHD1
SPOP therapeutic_target CHD1
CHD1 therapeutic_target Cancer
CHD1 associated_with Aging
CHD1 therapeutic_target Als
CHD1 associated_with Lipid Metabolism
CHD1 activates Cholesterol

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