concept

CYP17A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP17A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

0Analyses

35Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CYP17A1
Key Genes/Proteins	AMPK, APOPTOSIS, BAX, BCL-2, CYP19A1, Cytokine
Related Diseases	Als, Cancer, Glioblastoma
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    CYP17A1["CYP17A1"]
    CYP17A1 -->|"inhibits"| Cancer["Cancer"]
    CYP17A1 -->|"inhibits"| Als["Als"]
    CYP17A1 -->|"inhibits"| Inflammation["Inflammation"]
    CYP17A1 -->|"inhibits"| Obesity["Obesity"]
    CYP17A1 -->|"inhibits"| Insulin_Resistance["Insulin Resistance"]
    CYP17A1 -->|"activates"| Glioblastoma["Glioblastoma"]
    CYP17A1 -->|"inhibits"| STAR["STAR"]
    GATA6["GATA6"] -->|"regulates"| CYP17A1
    BAX["BAX"] -->|"inhibits"| CYP17A1
    ROS["ROS"] -->|"inhibits"| CYP17A1
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| CYP17A1
    INSULIN_RESISTANCE["INSULIN RESISTANCE"] -->|"inhibits"| CYP17A1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"inhibits"| CYP17A1
    AMPK["AMPK"] -->|"expressed in"| CYP17A1

Outgoing (35)

Target	Relation	Type	Str
Obesity	inhibits	disease	0.65
Insulin Resistance	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Cytokine	expressed_in	protein	0.60
CYP19A1	activates	gene	0.60
TNF	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
TNF-Α	expressed_in	gene	0.60
Insulin	expressed_in	protein	0.60
Nf-Κb	expressed_in	pathway	0.60
IL-1	expressed_in	gene	0.60
CYP19A1	expressed_in	gene	0.60
STAR	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
GBM	therapeutic_target	gene	0.60
HDAC6	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
DNA	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
SIRT1	expressed_in	gene	0.60
T Cell	inhibits	cell_type	0.60
BCL-2	inhibits	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
STAR	inhibits	gene	0.60
Nf-Κb	inhibits	pathway	0.60
NF-ΚB	inhibits	gene	0.60
P53	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
GENES	inhibits	gene	0.60

Incoming (17)

Source	Relation	Type	Str
GATA6	regulates	protein	0.85
AMPK	expressed_in	gene	0.60
INSULIN RESISTANCE	expressed_in	gene	0.60
STAR	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
SIRT1	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CYP19A1	expressed_in	gene	0.60
TNF-Α	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
BAX	inhibits	gene	0.60
ROS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYP17A1 in their description or question text

No additional research found