biomarker 2,622 words KG: PSP
Contents

DTI White Matter Changes in CBS/PSP

🔬 Protein Info
Gene SymbolPSP
Full NamePersephin
Chromosome19q13.33
Protein FamilyGDNF family
FunctionPersephin mediates its effects through specific receptor interactions:
PathwaysDifferentiation
GeneCardsPSP
Human Protein AtlasPSP
SNR (Signal-to-Noise Ratio)FA maps should have SNR > 20
Motion correctionMaximum displacement < 2mm between volumes
Eddy current correctionProper preprocessing is essential
Artifact assessmentCheck for slice dropout, Gibbs ringing
FAReduced in cerebral peduncles
MDElevated in substantia nigra
RDElevated (myelin loss)
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, dementia
InteractionsAGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections348 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (15)

Aquaporin-4 Polarization Rescue
Score: 0.73
Microglial Purinergic Reprogramming
Score: 0.70
Complement C1q Subtype Switching
Score: 0.66
Sphingolipid Metabolism Reprogramming
Score: 0.66
Glial Glycocalyx Remodeling Therapy
Score: 0.65

Related Analyses (8)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (30)

4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40

See Also (11)

Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_in
Frontotemporal Dementia (FTD)
disease · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_target
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

DUSP10 associated_with PSP
MAP1S associated_with PSP
PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
TAU activates PSP

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