disease 6,462 words KG: FTD
Contents

Frontotemporal Dementia (FTD)

Disease Info
Behavioral variant FTD (bvFTD)Progressive changes in personality, social conduct, and executive function, with early behavioral disinhibition, apathy, loss of empathy, and compulsive/ritualistic behaviors
Associated GenesACHE, AD, AKT, AMYLOID, APOE, APP, BDNF, C9orf72
KG Connections782 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Knowledge Graph

Related Hypotheses (30)

PARP1 Inhibition Therapy
Score: 0.74
Cross-Seeding Prevention Strategy
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
RNA Granule Nucleation Site Modulation
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (15)

Frontal and Temporal Lobe Selective Vulnerability in FTD — M
validation · proposed · Score: 0.40
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40
Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (15)

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Dise
biomarker · KG edge: co_discussed
FUS (Redirect)
redirect · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TAU associated_with FTD
TAU causes FTD
FTD inhibits MITOCHONDRIAL_PROTEINS
FTD inhibits BIOENERGETICS
FTD regulates TAU
TDP43 associated_with FTD
C9ORF72 causes FTD
VESICLE_TRAFFICKING associated_with FTD
GGGGCC_repeat causes FTD
FTD regulates MITOCHONDRIAL_PROTEINS

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