gene 712 words KG: MAP1S
Contents

MAP1S - Microtubule Associated Protein 1S

🧬 Gene Info
Gene SymbolMAP1S
Full NameMicrotubule Associated Protein 1S
AliasesPage for MAP1S
Chromosome19p13.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight55 kDa
UniProt IDQ9Y2R9
NCBI Gene ID55130
Ensembl IDENSG00000131370
OMIM607358
GeneCardsMAP1S
Human Protein AtlasMAP1S
LC3 interaction domainDirect binding to LC3 on autophagosomes
Microtubule-binding repeatsMultiple repeats that stabilize microtubules
Phosphorylation regulationActivity modulated by phosphorylation
Associated DiseasesAls, Alzheimer, Ms
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Astrocytes
cell · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
Progressive Supranuclear Palsy (PSP)
disease · KG edge: associated_with
Astrocytes
entity · KG edge: associated_with
DUSP10 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DUSP10 associated_with MAP1S
MAP1S associated_with PSP
MAP1S associated_with SP1
MAP1S associated_with APOE
MAP1S associated_with TAU
MAP1S associated_with KIF13A
MAP1S associated_with TRIM24
MAP1S associated_with STX6
MAP1S associated_with MAPT
MAP1S associated_with ALZHEIMER'S DISEASE

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