Contents

FOXO3 Gene

🧬 Gene Info

Gene Symbol	FOXO3
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	FOXO3-targeting drugs modulate the PI3K/Akt/FOXO3 signaling pathway to promote FOXO3 nuclear translocation and transcriptional activity, enhancing autophagy, stress resistance, and apoptosis in can...
Mechanism of Action	FOXO3-targeting drugs modulate the PI3K/Akt/FOXO3 signaling pathway to promote FOXO3 nuclear translocation and transcriptional activity, enhancing autophagy, stress resistance, and apoptosis in cancer cells. Indirect activators increase FOXO3 expression or prevent its degradation, thereby amplifying cellular protective responses.
Druggability	Low (0.42)
Clinical Stage	Approved
Molecular Weight	71 kDa
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Chaperone
UniProt ID	O43524
Ensembl ID	ENSG00000118445
GeneCards	FOXO3
Human Protein Atlas	FOXO3
Associated Diseases	Aging, Als, Alzheimer, AUTOPHAGY, Cancer
Known Drugs/Compounds	DEFERIPRONE, rapamycin, RAPAMYCIN, Ros, trehalose, TREHALOSE
Interactions	AD, AGING, AKT, ALOX15, ALS, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	FOXO3-Longevity Pathway Epigenetic Reprogramming
KG Connections	1004 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

No AI portrait yet

Knowledge Graph