concept

P16INK4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P16INK4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

1Hypotheses

5Analyses

37Outgoing

19Incoming

0Experiments

12Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	P16INK4A
Key Genes/Proteins	AGING, ALZHEIMER, APOPTOSIS, App, ATM, BAK1
Related Diseases	Aging, Als, ALS, Alzheimer, Ataxia
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    P16INK4A["P16INK4A"]
    P16INK4A -->|"activates"| senescence["senescence"]
    P16INK4A -->|"regulates"| Aging["Aging"]
    P16INK4A -->|"regulates"| Obesity["Obesity"]
    P16INK4A -->|"regulates"| Inflammation["Inflammation"]
    P16INK4A -->|"regulates"| Diabetes["Diabetes"]
    P16INK4A -->|"regulates"| Alzheimer["Alzheimer"]
    P16INK4A -->|"regulates"| ALS["ALS"]
    P16INK4A -.biomarker for.-> Senescence["Senescence"]
    GSK3B["GSK3B"] -->|"binds"| P16INK4A
    RB1["RB1"] -->|"regulates"| P16INK4A
    APOPTOSIS["APOPTOSIS"] -.biomarker for.-> P16INK4A
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| P16INK4A
    GENES["GENES"] -->|"regulates"| P16INK4A
    BCL2L1["BCL2L1"] -.biomarker for.-> P16INK4A
    CDKN2A["CDKN2A"] -->|"activates"| P16INK4A
    TP53["TP53"] -->|"activates"| P16INK4A

Outgoing (37)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:P16INK4A	data_in	dataset_row	0.00
Reactive Astrocytes	associated_with	cell_type	0.90
Cellular senescence	regulates	phenotype	0.90
CELLULAR_SENESCENCE	regulates	phenotype	0.90
senescence	activates	pathway	0.85
SENESCENCE	regulates	gene	0.70
senescent microglia	biomarker_for	cell_type	0.70
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	regulates	disease	0.65
Obesity	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	regulates	disease	0.65
ALS	regulates	disease	0.65
Senescence	biomarker_for	disease	0.65
Cancer	activates	disease	0.65
Ataxia	activates	disease	0.65
APOPTOSIS	biomarker_for	gene	0.60
ATM	activates	gene	0.60
T Cell	regulates	cell_type	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
Dna Repair	activates	pathway	0.60
Apoptosis	biomarker_for	pathway	0.60
DNA	activates	gene	0.60
P21CIP1	biomarker_for	gene	0.60
FAS	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
BCL2L1	biomarker_for	gene	0.60
BAK1	biomarker_for	gene	0.60
MMP1	regulates	gene	0.60
AGING	regulates	gene	0.60
App	regulates	protein	0.60
Rb	regulates	protein	0.60
Ras	regulates	protein	0.60
P21	biomarker_for	protein	0.60
T Cell	expressed_in	cell_type	0.55

Incoming (19)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:P16INK4A	data_in	dataset_row	0.00
CDKN2A	encodes	gene	0.90
38493185	was increased in	paper	0.90
RB1	regulates	gene	0.70
APOPTOSIS	biomarker_for	gene	0.60
CDKN2A	activates	gene	0.60
TP53	activates	gene	0.60
P53	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
AGING	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GENES	regulates	gene	0.60
BCL2L1	biomarker_for	gene	0.60
FAS	regulates	gene	0.60
MMP1	regulates	gene	0.60
P21CIP1	biomarker_for	gene	0.60
BAK1	biomarker_for	gene	0.60