protein

NLRP3 INFLAMMASOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP3 INFLAMMASOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

878Connections

16Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

1Debates

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🔬 Protein Info

Gene Symbol	NLRP3 INFLAMMASOME
CRID3	early selective inhibitor
MCC994	optimized analog
Associated Diseases	AGING, Alzheimer's Disease, APOPTOSIS, ATP, AUTISM
Known Drugs/Compounds	BERBERINE, EMPAGLIFLOZIN, FINGOLIMOD, FISETIN, MELATONIN, METFORMIN
Interactions	HSP90A, NAMO
KG Connections	344 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NLRP3 Inflammasome

entity · 1114 words

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Pathway Diagram

graph TD
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"activates"| Microglia["Microglia"]
    style Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"causes"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"associated"| IL_1_["IL-1Beta"]
    style IL_1_ fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"involved in"| Inflammatory_Diseases["Inflammatory Diseases"]
    style Inflammatory_Diseases fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"associated"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"involved in"| Glaucoma["Glaucoma"]
    style Glaucoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"causes"| Retinal_Ganglion_Cell_Death["Retinal Ganglion Cell Death"]
    style Retinal_Ganglion_Cell_Death fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    USP22["USP22"] -.->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style USP22 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    USP5["USP5"] -.->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style USP5 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF__B["NF-kappaB"] -->|"activates"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style NF__B fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    __SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"activates"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style __SYNUCLEIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Macrophage["Macrophage"] -->|"expressed in"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style Macrophage fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style NLRP3_INFLAMMASOME fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (303)

Target	Relation	Type	Str
pyroptosis	mediates	process	0.96
Microglia	activates	cell_type	0.95
Retinal Ganglion Cell Death	mediates	process	0.95
Retinal Ganglion Cell Death	contributes_to	phenotype	0.95
Pyroptosis	mediates	process	0.95
IL18	associated_with	protein	0.95
Neuroinflammation	contributes_to	process	0.95
Caspase-1 Activation	activates	mechanism	0.93
dementia progression	promotes	phenotype	0.92
Alzheimer's disease	associated_with	disease	0.92
IL1B	upregulates	gene	0.92
pathological inflammation	promotes	process	0.90
Alzheimer's Disease	associated_with	disease	0.90
Parkinson'S Disease	involved_in	disease	0.90
Inflammatory Diseases	involved_in	disease	0.90
neuroinflammation	promotes	process	0.90
AUTOPHAGY	inhibited_by	process	0.90
Pyroptosis	activates	process	0.90
Caspase-1 Activation	activates	process	0.90
Glaucoma	involved_in	disease	0.90
Neuroinflammation	causes	process	0.90
Neuroinflammation	causes	process	0.90
Phagocytic Function	inhibits	process	0.90
Retinal Ganglion Cell Death	causes	phenotype	0.90
IL-1Β	associated_with	protein	0.90
IL-18	associated_with	protein	0.90
Neuroinflammation	activates	process	0.90
Pyroptosis	associated_with	process	0.90
Neuroinflammation	mediates	process	0.90
Neuroinflammation	activates	process	0.90
IL1B	upregulates	protein	0.90
IL18	upregulates	protein	0.90
Liver inflammation	contributes_to	process	0.90
Inflammatory Diseases	involved_in	disease	0.90
neointima formation	promotes	process	0.90
GSDMD	activates	protein	0.90
neuroinflammation	drives	process	0.90
IL-1Β	associated_with	protein	0.90
Inflammatory Diseases	involved_in	disease	0.90
Microglia	activates	cell_type	0.90
Microglial Phagocytic Function	inhibits	process	0.88
cognitive decline	promotes	phenotype	0.88
IL1B	activates	protein	0.88
CASP1	activates	protein	0.88
Preeclampsia	contributes_to	disease	0.88
Neurodegeneration	contributes_to	phenotype	0.88
Neuroinflammation	mediates	process	0.88
IL-1β	upregulates	protein	0.88
Multiple Sclerosis	involved_in	disease	0.85
Tau Phosphorylation	mediates	process	0.85

Incoming (575)

Source	Relation	Type	Str
Neutrophil Extracellular Traps	activates	process	0.95
HDAC3	promotes	gene	0.95
GS-1	suppresses	compound	0.95
ZFP36	inhibits	gene	0.95
Polygala Saponins	inhibits	compound	0.95
TLR2	activates	gene	0.95
Tlr2 Inhibition	suppresses	mechanism	0.95
Usp9X Suppression	inhibits	mechanism	0.95
NLRP3	involved_in	protein	0.95
USP9X	regulates	gene	0.95
Carnosic Acid	inhibits	compound	0.95
Ciliatoside A	inhibits	compound	0.95
NLRP3	component_of	protein	0.95
Kaempferol	inhibits	compound	0.95
small-molecule inhibitors	inhibits	drug	0.95
REV-ERBα	inhibits	protein	0.95
Pg OMVs	activates	compound	0.95
A20	inhibits	protein	0.93
GS-1	inhibits	compound	0.92
NEK7	activates	protein	0.92
Ruxolitinib	inhibits	drug	0.92
USP5	attenuates	gene	0.90
31284572	mediates	paper	0.90
31284572	activate	paper	0.90
Donepezil	associated_with	drug	0.90
SEVOFLURANE	activates	compound	0.90
38421496	includes and activates	paper	0.90
Baohuoside I	inhibits	drug	0.90
SMPD1	activates	gene	0.90
HSP90A	activates	gene	0.90
NLRP3	part_of	gene	0.90
TFEB	inhibits	protein	0.90
39904963	activates	paper	0.90
AMPK	inhibits	protein	0.90
38989642	key pathway in	paper	0.90
Mitophagy	inhibits	process	0.90
Young plasma	modulates	compound	0.90
LCN2	activates	protein	0.90
CLEC16A	inhibits	gene	0.90
Biomechanical Strain	activates	process	0.88
Biomechanical Strain	activates	process	0.88
Mitochondrial Damage	activates	process	0.88
Frostbite Injury	upregulates	disease	0.88
autophagy-lysosomal pathway	downstream_of	pathway	0.88
CB13	inhibits	drug	0.87
GPER	inhibits	protein	0.87
NF-κB	activates	pathway	0.87
DS-HMGB1	activates	protein	0.85
PARKIN	regulates	gene	0.85
P2X7R	activates	receptor	0.85

Targeting Hypotheses (16)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.822	neurodegeneration	What are the mechanisms by which gut mic
NLRP3 Inflammasome Lock Perpetuates Senescence-Associated In	0.720	neurodegeneration	What molecular mechanisms drive microgli
C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macropha	0.631	neuroinflammation	What are the specific molecular mechanis
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.625	neuroscience	Lysosomal dysfunction and cathepsin leak
NLRP3 Inflammasome Priming Converts SCFA-Sensitive Pyroptosi	0.620	neurodegeneration	How does gut microbiome dysbiosis contri

Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak
NLRP3 Inflammasome Inhibition Prevents Synapse Loss via IL-1	0.610	neurodegeneration	Test Preregistration Analysis
Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP	0.590	neurodegeneration	What are the optimal oxygen pressure, du
NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumul	0.566	developmental neurobiology	Do perinatal immune challenges create pe
NLRP3 Inflammasome Blockade as Upstream Intervention to Prev	0.566	neurodegeneration	Why have numerous phase 3 clinical trial
P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming	0.563	biomarkers	What biomarkers can reliably detect micr
TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inf	0.485	Neuroinflammation	Immune atlas neuroinflammation analysis
Sub-antidepressant Doses Suppress NLRP3 Inflammasome via P2X	0.465	-	What is the minimum effective dose of tr
STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia	0.380	Neuroinflammation	Immune atlas neuroinflammation analysis
Circulating hs-CRP as Disease-Modifying Target via Astrocyti	0.380	immunomics	Systemic immune profiling in neurodegene
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglial subtypes in neurodegeneration — friend vs foe

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.685

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Molecular characterization of RBG-NLRP3 binding interaction	exploratory	atherosclerosis	0.900	purified proteins and molecula	proposed	N/A
Leukocyte gene expression analysis in COVID-19 patients	exploratory	COVID-19	0.900	human leukocytes from COVID-19	proposed	N/A
RBG effects on macrophage polarization and foam cell formation	exploratory	atherosclerosis	0.850	primary macrophages	proposed	N/A
Transcriptomic analysis of RBG effects on inflammatory gene expression	exploratory	atherosclerosis	0.800	ApoE-/- mice and cell cultures	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438]	Hegdekar N, Sarkar C, Bustos S, Ritzel R	Autophagy	2023
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's [PMID:37029500]	Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH,	Aging cell	2023
Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like [PMID:36288697]	Li S, Fang Y, Zhang Y, Song M, Zhang X,	Cell reports	2022
Biomarker of Neuroinflammation in Parkinson's Disease. [PMID:35456966]	Liu TW, Chen CM, Chang KH	Int J Mol Sci	2022
NLRP3 inflammasome activation drives tau pathology. [PMID:31748742]	["Ising C", "Venegas C", "Zhang S", "Sch	Nature	2019

Debates (1)

Multi-agent debates referencing this entity

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning NLRP3 INFLAMMASOME in their description or question text

Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 infla

Score: 0.620 · neuroscience · 2026-04-22

## Mechanistic Overview Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 inflammasome activati

NLRP3 Inflammasome Inhibition Prevents Synapse Loss via IL-1β Suppression

Score: 0.610 · neurodegeneration · 2026-04-28

NLRP3 inflammasome activation releases IL-1β, driving complement cascade upregulation and synapse elimination. MCC950 or

Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP3 inflammasome and s

Score: 0.590 · neurodegeneration · 2026-04-25

This hypothesis proposes that HBOT reduces ROS-mediated NF-κB activation and NLRP3 inflammasome assembly, promoting anti

NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation

Score: 0.566 · developmental neurobiology · 2026-04-21

## Mechanistic Overview NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation starts from the claim that mod

NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplificati

Score: 0.566 · neurodegeneration · 2026-04-16

## Mechanistic Overview NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplification starts from t

P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming

Score: 0.563 · biomarkers · 2026-04-22

## Mechanistic Overview P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming starts from the claim that modulatin

TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation

Score: 0.485 · Neuroinflammation · 2026-04-21

## Mechanistic Overview TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation starts from the

Sub-antidepressant Doses Suppress NLRP3 Inflammasome via P2X7 Receptor Blockade

Score: 0.465 · unknown disease · 2026-04-26

Trazodone acts as a weak antagonist at P2X7 purinergic receptors (IC50 ~3 micromolar), suppressing microglial NLRP3 infl

STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia

Score: 0.380 · Neuroinflammation · 2026-04-26

This hypothesis proposes that cytoplasmic mtDNA released from TDP-43-damaged mitochondria in ALS activates the cGAS-STIN

Circulating hs-CRP as Disease-Modifying Target via Astrocytic NLRP3 Inflammasome

Score: 0.380 · immunomics · 2026-04-27

Elevated circulating high-sensitivity C-reactive protein (hs-CRP) serves as a disease-modifying target through direct ac

NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhibition

Score: 0.105 · neurodegeneration · 2026-04-18

## Mechanistic Overview NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhibition starts from the claim that mod