protein

REV-ERBΑ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REV-ERBΑ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

2Analyses

14Outgoing

7Incoming

0Experiments

2Debates

Summary

Page for REV-ERBα Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	REV
Protein Family	Nuclear receptor family, REV-ERB subfamily
Subcellular Localization	signal - Ligand-binding domain (LBD): Binds heme as an endogenous ligand; co
Molecular Weight	~51 kDa
Pathways	circadian regulation
UniProt ID	Q9UGL9
GeneCards	REV
Human Protein Atlas	REV
Associated Diseases	ALS
Known Drugs/Compounds	lithium
Interactions	BMAL1, CLOCK, HDAC3
KG Connections	24 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Pathway Diagram

graph TD
    REV_ERB("REV-ERBAlpha")
    Lipid_Metabolism["Lipid Metabolism"]
    REV_ERB -->|"modulates"| Lipid_Metabolism
    Neuroinflammation["Neuroinflammation"]
    REV_ERB -->|"modulates"| Neuroinflammation
    DOPAMINERGIC["DOPAMINERGIC"]
    REV_ERB -->|"activates"| DOPAMINERGIC
    DOPAMINE["DOPAMINE"]
    REV_ERB -->|"activates"| DOPAMINE
    Melatonin["Melatonin"]
    REV_ERB -->|"activates"| Melatonin
    inflammation(["inflammation"])
    REV_ERB -->|"regulates"| inflammation
    LIPID_METABOLISM(["LIPID METABOLISM"])
    REV_ERB -->|"regulates"| LIPID_METABOLISM
    CLOCK["CLOCK"]
    CLOCK -->|"co_discussed"| REV_ERB
    GABA["GABA"]
    GABA -->|"co_discussed"| REV_ERB
    GENES["GENES"]
    GENES -->|"co_discussed"| REV_ERB
    GABA -->|"activates"| REV_ERB
    microglia["microglia"]
    microglia -->|"associated_with"| REV_ERB

Outgoing (14)

Target	Relation	Type	Str
NLRP3 Inflammasome	inhibits	pathway	0.95
Microglial Activation	regulates	process	0.92
NF-κB Pathway	regulates	pathway	0.85
INFLAMMATION	modulates	process	0.80
Substantia Nigra	expressed_in	brain_region	0.80
Neuroinflammation	modulates	process	0.75
Lipid Metabolism	modulates	process	0.75
circadian_rhythm	regulates	pathway	0.70
neural function	regulates	process	0.70
Bmal1 transcription	inhibits	process	0.70
LIPID METABOLISM	regulates	pathway	0.50
inflammation	regulates	pathway	0.50
DOPAMINERGIC	activates	concept	0.50
DOPAMINE	activates	concept	0.50

Incoming (7)

Source	Relation	Type	Str
SR9009	activates	drug	0.93
miR-132	inhibits	gene	0.70
GABA	activates	gene	0.50
microglia	associated_with	cell_type	0.50
CLOCK	co_discussed	gene	0.50
GABA	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can circadian interventions selectively target microglia without affecting other

neuropharmacology | 2026-04-10 | 0 hypotheses

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate highlighted a critical cell-type specificity gap where no evidence ex

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

What are the mechanisms underlying digital biomarkers and ai-driven early detect

closed · Rounds: 4 · Score: 0.86 · 2026-04-01

Related Research

Hypotheses and analyses mentioning REV-ERBΑ in their description or question text

No additional research found